Gilbert's

Gilbert's syndrome is a common, benign genetic liver disorder. It is characterized by intermittent, mild jaundice resulting from elevated levels of unconjugated bilirubin in the bloodstream. The syndrome is named after French physician Augustin Nicolas Gilbert and his colleagues who first described it in 1901.

Symptoms

The primary symptom of Gilbert's syndrome is mild, intermittent jaundice, caused by elevated levels of unconjugated bilirubin in the bloodstream. Other symptoms may include fatigue, weakness, and abdominal pain. However, many individuals with Gilbert's syndrome do not experience any symptoms.

Causes

Gilbert's syndrome is caused by a mutation in the UGT1A1 gene. This gene provides instructions for making an enzyme that helps break down bilirubin in the liver. In people with Gilbert's syndrome, the enzyme's activity is reduced, leading to increased levels of bilirubin in the blood.

Diagnosis

Gilbert's syndrome is typically diagnosed through a blood test that measures bilirubin levels. Genetic testing can also be used to identify the mutation in the UGT1A1 gene.

Treatment

There is no specific treatment for Gilbert's syndrome. Management of the condition typically involves monitoring bilirubin levels and managing any symptoms. In some cases, changes to diet and lifestyle may be recommended.

See also

• Jaundice
• Liver disease
• Genetic disorder

References

Gilbert's Resources
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