HDAC3

HDAC3 or Histone Deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene. HDAC3 belongs to the histone deacetylase family, which plays a key role in the regulation of eukaryotic gene expression.

Function

HDAC3 is a component of the nuclear receptor co-repressor complex (N-CoR), and it is known to play a crucial role in the regulation of gene expression. The proteins in this complex, including HDAC3, are considered to be transcription factors, which are proteins that control the rate of transcription of genetic information from DNA to messenger RNA.

Structure

The HDAC3 protein has a molecular weight of approximately 49 kDa and is composed of 428 amino acids. The structure of HDAC3 is similar to that of other histone deacetylases, with a large, highly conserved catalytic domain and a smaller, less conserved C-terminal domain.

Clinical Significance

HDAC3 has been implicated in a variety of human diseases, including cancer, neurodegenerative diseases, and inflammatory diseases. In cancer, overexpression of HDAC3 has been observed in several types of tumors, suggesting that it may play a role in tumor progression and metastasis. In neurodegenerative diseases, HDAC3 has been shown to regulate neuronal death, and its inhibition has been proposed as a potential therapeutic strategy. In inflammatory diseases, HDAC3 has been found to regulate the expression of inflammatory genes, suggesting that it may be a potential target for anti-inflammatory therapies.

See Also

• Histone Deacetylase
• Gene Expression
• Transcription Factor
• Cancer
• Neurodegenerative Diseases
• Inflammatory Diseases

References

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