HIG1 hypoxia inducible domain family member 1B

HIG1 hypoxia inducible domain family member 1B (also known as HIGD1B) is a protein that in humans is encoded by the HIGD1B gene. This protein is a member of the HIG1 family and plays a crucial role in the cellular response to hypoxia, a condition where the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

Function

HIGD1B is a mitochondrial protein that is induced by hypoxia and is part of the hypoxia-inducible factor (HIF) pathway. It is involved in the regulation of cell death and cell survival under hypoxic conditions. The exact mechanism of how HIGD1B functions is still under investigation, but it is believed to play a role in the stabilization of the mitochondrial membrane potential and in the prevention of apoptosis, or programmed cell death.

Clinical Significance

Alterations in the HIGD1B gene have been associated with various diseases. For instance, mutations in this gene have been linked to cancer, as the hypoxic environment within tumors can lead to the overexpression of HIGD1B. This overexpression can promote tumor growth and resistance to therapy. Furthermore, HIGD1B has been implicated in cardiovascular disease, as hypoxia is a common condition in heart disease.

Research

Research on HIGD1B is ongoing, with scientists aiming to understand its exact role in hypoxia and its potential as a therapeutic target for diseases associated with hypoxia, such as cancer and cardiovascular disease.

See Also

• Hypoxia (medical)
• Hypoxia-inducible factors
• Mitochondrion
• Apoptosis

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