HIST1H3E

Protein HIST1H3E PDB 1aoi

HIST1H3E

HIST1H3E is a gene that encodes a member of the histone H3 family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H3E gene is located on chromosome 6 in humans.

Function

The protein encoded by HIST1H3E is a core component of nucleosomes, which are the basic units of chromatin. Chromatin is the complex of DNA and proteins that make up chromosomes. Histones like HIST1H3E help regulate gene expression by controlling access to the DNA.

Structure

HIST1H3E belongs to the histone H3 family, which includes several variants with similar functions. The protein structure of HIST1H3E is characterized by a globular domain and a flexible tail. Post-translational modifications of the histone tail can influence chromatin structure and gene expression.

Role in Epigenetics

Epigenetic modifications, such as histone methylation and acetylation, can alter the function of histones like HIST1H3E. These modifications can affect gene expression patterns without changing the underlying DNA sequence. HIST1H3E is involved in epigenetic regulation of gene activity.

Clinical Significance

Aberrant expression or mutations in HIST1H3E have been associated with various diseases, including cancer. Dysregulation of histone genes can disrupt normal chromatin structure and contribute to tumorigenesis. Understanding the role of HIST1H3E in disease may lead to potential therapeutic targets.