HLA-A30

HLA-A30 is a human leukocyte antigen (HLA) serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α30 subset of the HLA-A locus. HLA-A30 is a cell surface protein that plays a crucial role in the regulation of the immune system in humans.

Function

HLA-A30 is part of the HLA-A gene complex, which encodes the major histocompatibility complex (MHC) class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane of the cell. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.

Role in Disease

HLA-A30 has been associated with a variety of diseases. For example, it has been linked to an increased risk of hepatitis C infection and progression to cirrhosis. It has also been associated with a decreased risk of HIV progression.

Distribution

HLA-A30 is found at highest frequencies in certain populations in West Africa, South America, and Europe. It is less common in East Asia and North America.

See Also

• HLA-A
• Human leukocyte antigen
• Major histocompatibility complex
• Immune system

References

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