HLA-B13

HLA-B13 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B13. This serotype is a product of the HLA-B gene, which is a member of the MHC class I molecules.

Function

HLA-B13 is a cell surface protein involved in the regulation of the immune system. It plays a crucial role in the immune response by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B13 can present these peptides to T lymphocytes, a type of white blood cell that plays a central role in cell-mediated immunity.

Clinical significance

HLA-B13 has been associated with a number of diseases. It is linked to a slower progression of HIV infection to AIDS, possibly due to its role in the immune response. It has also been associated with an increased risk of psoriasis, a chronic skin condition, and Behçet's disease, a rare disorder that causes blood vessel inflammation throughout the body.

Distribution

HLA-B13 is found in high frequencies in certain populations, including those in West Africa and South Asia. It is less common in populations from Europe and North America.

See also

• HLA-B
• Human leukocyte antigen
• MHC class I

References

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