HLA-B54

HLA-B54 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that play a crucial role in the immune system function in humans. HLA-B54 is part of the HLA-B locus, a subcategory of HLA class I molecules.

Function

HLA-B54, like other HLA class I molecules, is involved in the presentation of peptides (small proteins) to the T cells of the immune system. This process is essential for the immune system to recognize and respond to foreign substances, such as viruses and bacteria.

Genetics

HLA-B54 is encoded by the HLA-B*54 gene allele, a variant form of the HLA-B gene. The HLA-B*54 allele is relatively rare, but it has been identified in certain populations, including some groups in Japan and Korea.

Clinical significance

HLA-B54 has been associated with a number of medical conditions. For example, it has been linked to a higher risk of Hepatitis B infection and a lower risk of HIV progression. However, more research is needed to fully understand these associations and their implications for disease prevention and treatment.

See also

• HLA-B
• Human leukocyte antigen
• Immune system
• T cell