HLA-B55

HLA-B55 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system. HLA-B55 is part of the HLA-B serotype group, which is located on the short arm of chromosome 6 (6p21.3).

Function

HLA-B55 is involved in the immune response by presenting peptides (small proteins) from within the cell to T cells, a type of white blood cell. This allows the immune system to detect and respond to pathogens and other foreign substances.

Association with Disease

HLA-B55 has been associated with several diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease. It is also associated with a higher risk of HIV progression.

Genetic Diversity

Like many HLA genes, HLA-B55 is highly polymorphic, meaning it has many different forms. This diversity is thought to allow the immune system to respond to a wide range of pathogens.

See Also

• HLA-B
• Human leukocyte antigen
• Immune system
• T cells

References

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