HLA-B62

HLA-B62 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are crucial for the function of the immune system. HLA-B62 is a broad antigen serotype that is further divided into HLA-B15 and HLA-B40 split antigen serotypes.

Structure and Function

HLA-B62 is a cell surface protein that is encoded by the B locus of the Major Histocompatibility Complex (MHC) on chromosome 6. It plays a vital role in the immune system's recognition and response to foreign antigens. The protein is composed of a heavy chain and a light chain, which together form a groove for peptide binding. This peptide-MHC complex is then presented to T cells, triggering an immune response.

Clinical Significance

HLA-B62 has been associated with various autoimmune and infectious diseases. For instance, it has been linked to an increased risk of rheumatoid arthritis, celiac disease, and certain types of cancer. It is also involved in the immune response to infections such as HIV and hepatitis C.

See Also

• Human leukocyte antigen
• Major Histocompatibility Complex
• Autoimmune disease
• Infectious disease

References

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