HLA-B75

HLA-B75 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are important in the immune system's ability to distinguish the body's own proteins from proteins made by foreign invaders like viruses and bacteria. HLA-B75 is part of the HLA-B serotype group, which is one of the three major types of HLA molecules found on the surface of cells.

Structure and Function

HLA-B75 is a cell surface protein that plays a crucial role in the regulation of the immune response. It is involved in the presentation of foreign antigens to the immune system. The HLA-B75 molecule is a heterodimer, consisting of a heavy chain and a light chain, also known as beta-2 microglobulin. The heavy chain is encoded by the HLA-B gene, while the light chain is a common component of all class I molecules.

Role in Disease

Certain alleles of HLA-B75 have been associated with an increased risk of developing certain diseases. For example, HLA-B75 has been linked to an increased susceptibility to HIV infection and progression to AIDS. It has also been associated with certain autoimmune diseases, such as ankylosing spondylitis and Behcet's disease.

Testing and Typing

HLA-B75 typing can be performed using various methods, including serology, polymerase chain reaction (PCR), and sequence-based typing (SBT). These tests can help determine an individual's HLA-B75 status, which can be useful in a variety of clinical settings, such as organ transplantation and disease risk assessment.

See Also

• HLA-B
• Human leukocyte antigen
• Beta-2 microglobulin
• Ankylosing spondylitis
• Behcet's disease

References

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