HLA-DR10

HLA-DR10 is a human leukocyte antigen (HLA) serotype that is part of the HLA-DR serotype group. The HLA-DR10 serotype is determined by the HLA-DRB1*10 allele group, which is a part of the larger HLA-DRB1 gene locus. This serotype is involved in the immune system's recognition and response to pathogens.

Function

HLA-DR10, like other HLA-DR serotypes, plays a crucial role in the immune system. It is involved in the presentation of antigens to T cells, which is a key step in the immune response to infections. The HLA-DR10 molecule presents peptides derived from extracellular proteins to CD4+ T cells, which then initiate an immune response.

Genetics

The HLA-DR10 serotype is encoded by the HLA-DRB1*10 allele group. This group is part of the larger HLA-DRB1 gene locus, which is located on the short arm of chromosome 6 (6p21.3). The HLA-DRB1 gene locus is highly polymorphic, meaning that there are many different versions of the gene in the human population. This genetic diversity is thought to contribute to the ability of the immune system to respond to a wide range of pathogens.

Clinical significance

HLA-DR10 has been associated with several autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Studies have found that individuals with the HLA-DR10 serotype have an increased risk of developing these diseases. However, the exact role of HLA-DR10 in these diseases is not fully understood and is the subject of ongoing research.

See also

• HLA-DR
• HLA-DRB1
• Human leukocyte antigen