HLA-DR13

HLA-DR13 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β-subunit of HLA-DR. This β-subunit is encoded by HLA-DRB1 gene and HLA-DR13 is encoded by the HLA-DRB1*13 allele group. This group currently contains many alleles. HLA-DR13 and HLA-DR14 split from a common ancestor, HLA-DR6.

Function

HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex is a group of genes that code for proteins found on the surface of cells that help the immune system to recognize foreign substances. HLA-DR is an antigen-presenting cell that is important in initiating immune responses.

Disease Association

HLA-DR13 is associated with a decreased risk of rheumatoid arthritis, systemic lupus erythematosus, and HIV infection. It is also associated with a decreased risk of progression to AIDS in HIV-infected individuals. However, it is associated with an increased risk of hepatitis B infection and leprosy.

Alleles

HLA-DRB1*13 group contains many alleles including DRB1*1301, DRB1*1302, DRB1*1303, DRB1*1304, and DRB1*1305. Each allele has a slightly different protein sequence, but all belong to the HLA-DR13 serotype group.

See Also

• HLA-DR
• HLA-DRB1
• MHC class II
• Antigen-presenting cell
• Human leukocyte antigen