HLA-DR16

HLA-DR16 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β-subunit of HLA-DR. This β-subunit is encoded by HLA-DRB1 gene. HLA-DR16 is a split antigen of the broad antigen HLA-DR2, and it is in linkage disequilibrium with HLA-DQ1.

Function

HLA-DR is a cell surface receptor involved in the regulation of the immune system. It plays a crucial role in the immune response by presenting peptides derived from extracellular proteins to T cells. HLA-DR16, like other HLA-DR antigens, is expressed in antigen-presenting cells (APCs), including macrophages and dendritic cells.

Disease association

HLA-DR16 has been associated with several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the exact role of HLA-DR16 in these diseases is not fully understood and is the subject of ongoing research.

Genetics

The HLA-DR16 gene is located on chromosome 6, in a region known as the major histocompatibility complex (MHC). The MHC is a highly gene-dense region and is the most gene-dense region of the human genome.

See also

• HLA-DR
• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease