HLA-DR3

HLA-DR3 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of antigens. HLA-DR3 is a split antigen of the broad antigen HLA-DR17, which is now obsolete. HLA-DR3 is associated with several autoimmune diseases, including type 1 diabetes, coeliac disease, and systemic lupus erythematosus.

Structure and Function

HLA-DR3 is a cell surface glycoprotein that plays a crucial role in the immune system. It is part of the major histocompatibility complex (MHC) class II, which presents antigens to the T cells. The HLA-DR3 antigen is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane.

Disease Associations

HLA-DR3 is associated with a variety of autoimmune diseases. These include:

• Type 1 diabetes: HLA-DR3 and HLA-DR4 are the most common serotypes associated with this disease. The presence of these serotypes increases the risk of developing type 1 diabetes.

• Coeliac disease: HLA-DR3 is found in up to 95% of patients with coeliac disease. The presence of HLA-DR3 is a strong predictor of the development of coeliac disease.

• Systemic lupus erythematosus: HLA-DR3 is associated with an increased risk of developing systemic lupus erythematosus, particularly in individuals of European descent.

See Also

• HLA-DR
• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease

References

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