HOT-2

HOT-2 (also known as 2,5-dimethoxy-4-ethylthioamphetamine) is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and documented in his book, PiHKAL (Phenethylamines I Have Known And Loved).

History

HOT-2 was first synthesized and studied by Alexander Shulgin. The detailed synthesis and personal bioassay information was published in his book PiHKAL. The compound is part of a series of psychedelic phenethylamines, collectively referred to as the HOT series, which were developed by Shulgin for their psychoactive properties.

Chemistry

HOT-2 is a derivative of 2C-H, which is a primary amine of the 2C family. The chemical structure consists of a phenethylamine core, with an additional ethylthio group attached to the 4th position of the phenyl ring, and two methoxy groups attached at the 2nd and 5th positions.

Pharmacology

Like other psychedelic phenethylamines, HOT-2 is thought to act primarily as a 5-HT2A receptor agonist. This receptor is involved in the release of the neurotransmitter serotonin, which plays a role in regulating mood, appetite, sleep, and other functions. The exact mechanism of action, however, is not fully understood.

Effects

The effects of HOT-2 are similar to other psychedelic phenethylamines, and can include visual hallucinations, enhanced perception, euphoria, and altered thought patterns. The duration of effects typically lasts between 6 to 8 hours, but can vary depending on the dose and individual metabolism.

Legal Status

The legal status of HOT-2 varies by country. In the United States, it is not specifically listed as a controlled substance, but it could potentially be considered an analog of a controlled substance under the Federal Analogue Act.

See Also

• 2C-E
• 2C-I
• 2C-T-2
• 2C-T-7
• 2C-B
• 2C-C