HOXA7

HOXA7 is a gene that belongs to the homeobox family of genes. The protein encoded by this gene is a transcription factor that plays a crucial role in embryonic development and cell differentiation.

Structure

The HOXA7 gene is located on the short (p) arm of chromosome 7 at position 15.2. It spans approximately 6.3 kilobases and consists of two exons. The encoded protein is 252 amino acids in length and contains a conserved homeobox domain, which allows it to bind to specific DNA sequences and regulate gene expression.

Function

HOXA7 is part of the HOX gene family, which is a group of transcription factors that regulate the body plan of an embryo along the anterior-posterior axis. HOXA7 is expressed in the first trimester of pregnancy, particularly in the developing foregut and neural tube. It is also expressed in adult tissues such as the uterus, ovary, and colon.

Clinical Significance

Mutations in the HOXA7 gene have been associated with various types of cancer, including breast cancer, ovarian cancer, and colorectal cancer. Overexpression of HOXA7 has been observed in these cancers, suggesting that it may play a role in tumorigenesis. However, the exact mechanisms by which HOXA7 contributes to cancer development are still under investigation.

Research

Current research is focused on understanding the role of HOXA7 in cancer development and progression. Studies are also being conducted to explore the potential of HOXA7 as a therapeutic target for cancer treatment.

See Also

• Homeobox
• Transcription factor
• HOX gene
• Cancer