Haplotype

Haplotype is a combination of DNA sequences at adjacent locations (loci) on the chromosome that are transmitted together. A haplotype can refer to a combination of alleles or to a set of single nucleotide polymorphisms (SNPs) found on a single chromosome.

Definition

The term "haplotype" is derived from the phrase "haploid genotype". In this context, "haploid" refers to the single set of chromosomes in a gamete, while "genotype" refers to the genetic makeup of an organism. Therefore, a haplotype is a specific combination of genes or DNA sequences that are inherited together from a single parent.

Importance in Medical Research

Haplotypes are important in medical research because they can help scientists identify genetic factors associated with diseases. For example, certain haplotypes may be associated with an increased risk of developing specific diseases, such as cancer, heart disease, or diabetes. By studying haplotypes, researchers can better understand the genetic basis of these and other diseases.

Haplotype Mapping

Haplotype mapping is a method used to identify the location of disease-related genes. This method involves comparing the haplotypes of individuals with a disease to those without the disease. Differences in haplotypes between these two groups can indicate the location of genes that contribute to the disease.

See Also

• Genotype
• Phenotype
• Genome
• Genetic variation
• Genetic linkage

References

Haplotype Resources
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