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Homatropine methylbromide is a quinuclidine derivative and muscarinic antagonist used in the treatment of various medical conditions. It is a non-selective competitive antagonist at the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5.

Pharmacology

Homatropine methylbromide is a parasympatholytic agent that works by blocking the responses to acetylcholine that occur in the muscles of the gastrointestinal tract, the bladder, and the eye. This results in a decrease in gastric secretions and a reduction in the motility of the gastrointestinal tract.

Medical uses

Homatropine methylbromide is used in the treatment of gastrointestinal disorders such as irritable bowel syndrome and peptic ulcer disease. It is also used in the treatment of diverticulitis and pancreatitis. In ophthalmology, it is used as a mydriatic to dilate the pupil during eye examinations.

Side effects

The most common side effects of homatropine methylbromide include dry mouth, blurred vision, and sensitivity to light. Less common side effects include confusion, tachycardia, and difficulty urinating.

Contraindications

Homatropine methylbromide is contraindicated in patients with glaucoma, as it can increase intraocular pressure. It is also contraindicated in patients with myasthenia gravis, as it can exacerbate the condition.

See also

• Muscarinic antagonist
• Parasympatholytic
• Mydriatic