Homeobox A10

Homeobox A10 (HOXA10) is a gene that encodes a DNA-binding protein belonging to the homeobox family of genes. The HOXA10 gene is located on the long (q) arm of chromosome 7 at position 15.2.

Function

The HOXA10 gene provides instructions for making a protein that plays a crucial role in the development of the limbs, uterus, cervix, and fallopian tubes. This protein binds to specific areas of DNA and helps control the activity of particular genes. As a transcription factor, it is involved in regulating the process by which genetic information is copied from DNA to RNA (transcription).

Clinical Significance

Mutations in the HOXA10 gene have been associated with endometriosis, recurrent pregnancy loss, and certain types of cancer, including leukemia and ovarian cancer. Studies have shown that abnormal expression of the HOXA10 gene may contribute to the development of these conditions.

Research

Research is ongoing to better understand the role of the HOXA10 gene in human development and disease. This includes studies into its role in embryogenesis, the process by which the embryo forms and develops.

See Also

• Homeobox
• Gene
• Transcription factor
• Endometriosis
• Ovarian cancer