Homo-MDA

Chemical compound

Homo-MDA
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	207740-32-1
PubChem	4433
DrugBank
ChemSpider	4278
KEGG

Homo-MDA (3,4-methylenedioxy-N-methylamphetamine) is a psychoactive drug and a member of the amphetamine class of chemicals. It is structurally related to MDMA (3,4-methylenedioxy-N-methylamphetamine) and is known for its stimulant and empathogenic effects.

Chemical Structure and Properties

Homo-MDA is a derivative of amphetamine and is characterized by the presence of a methylenedioxy group attached to the phenyl ring. The chemical structure of Homo-MDA is similar to that of MDMA, with the primary difference being the addition of a methylene bridge, which extends the side chain by one carbon atom. This structural modification is responsible for its unique pharmacological properties.

Chemical structure of Homo-MDA

Pharmacology

Homo-MDA acts primarily as a serotonin releasing agent, similar to other members of the MDxx class. It increases the levels of serotonin in the synaptic cleft by promoting the release of serotonin from presynaptic neurons. This action is responsible for its mood-enhancing and empathogenic effects. Additionally, Homo-MDA has some affinity for dopamine and norepinephrine transporters, contributing to its stimulant properties.

Effects

The effects of Homo-MDA are similar to those of MDMA, including increased energy, enhanced mood, and heightened sensory perception. Users may experience feelings of empathy and emotional closeness, which are characteristic of empathogens. However, the specific effects can vary depending on the dose and individual differences in metabolism and sensitivity.

Legal Status

The legal status of Homo-MDA varies by country. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to MDMA and its potential for abuse. It is important for researchers and users to be aware of the legal implications of possessing or distributing Homo-MDA.

Synthesis

The synthesis of Homo-MDA involves the use of safrole or isosafrole as starting materials, which are then subjected to a series of chemical reactions to introduce the methylenedioxy group and the extended side chain. The synthesis requires expertise in organic chemistry and access to specialized laboratory equipment.

Related Compounds

Homo-MDA is part of a larger family of phenethylamines and amphetamines, which includes compounds such as MDMA, MDA, and MDEA. These compounds share similar chemical structures and pharmacological effects, but differ in their potency and duration of action.

Related Pages

• MDMA
• Amphetamine
• Serotonin
• Empathogen