Hormesis

From WikiMD's Wellnesspedia

Hormesis is a biological phenomenon where a beneficial effect (improved health, stress tolerance, growth or longevity) results from exposure to low doses of an agent that is otherwise toxic or lethal when given at higher doses.

Definition[edit | edit source]

Hormesis is characterized by dose-response relationships displaying low-dose stimulation and high-dose inhibition. Hormesis is observed also in the responses of many animals to certain levels of all types of stressors. The hormesis model of dose-response is vigorously debated. The biological mechanisms by which this occurs are not well understood, although a number of theories have been proposed.

History[edit | edit source]

The term "hormesis" comes from the Greek word hormo, which means "to excite". It was first used in the scientific literature in 1943 by Southam and Ehrlich.

Mechanisms[edit | edit source]

The mechanisms of hormesis are varied and can involve a multitude of pathways. Some of the proposed mechanisms include the upregulation of protective enzymes and stress response genes, the activation of immune responses, and the increased production of antioxidants.

Applications[edit | edit source]

Hormesis has potential applications in many areas such as toxicology, risk assessment, radiation protection, aging research, and medicine.

See also[edit | edit source]

References[edit | edit source]


Hormesis Resources

Find a healthcare provider anywhere in the world quickly and easily!

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Admin, Prab R. Tumpati, MD