Huntington's disease-like syndrome

Huntington's disease-like syndrome is a group of inherited disorders that are similar in many ways to Huntington's disease. The disorders are characterized by a triad of symptoms: movement abnormalities, cognitive decline, and psychiatric disturbances.

Symptoms[edit | edit source]

The symptoms of Huntington's disease-like syndrome are similar to those of Huntington's disease. They include:

Chorea: Uncontrolled, irregular, jerky movements
Dystonia: Involuntary muscle contractions that cause slow repetitive movements or abnormal postures
Parkinsonism: Symptoms similar to those of Parkinson's disease, such as bradykinesia (slowness of movement), rigidity (stiffness), and tremor
Cognitive decline: Problems with memory, judgment, and thinking
Psychiatric disturbances: Depression, anxiety, and changes in personality or behavior

Causes[edit | edit source]

Huntington's disease-like syndrome is caused by mutations in several different genes. The most common are the PRNP gene (Huntington's disease-like 1), the JPH3 gene (Huntington's disease-like 2), the TBP gene (Huntington's disease-like 4), and the SCA17 gene (Huntington's disease-like 4).

Diagnosis[edit | edit source]

Diagnosis of Huntington's disease-like syndrome is based on the symptoms, family history, and genetic testing.

Treatment[edit | edit source]

There is no cure for Huntington's disease-like syndrome. Treatment is focused on managing the symptoms and improving quality of life. This may include medications to control movement problems, therapy to manage psychiatric symptoms, and supportive care.

See also[edit | edit source]

Huntington's disease-like syndrome Resources
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