Hy's law

Hy's law is a medical principle that is used to predict the likelihood of a drug-induced liver injury (DILI) in patients. It is named after the scientist Hyman Zimmerman, who first proposed this concept in the 1960s. According to Hy's law, a drug is considered to be the cause of liver injury if the following criteria are met:

1. The patient exhibits signs and symptoms of liver injury, such as jaundice, elevated liver enzymes, and hepatomegaly. 2. There is no other plausible explanation for the liver injury, such as viral hepatitis or alcohol abuse. 3. The onset of liver injury occurs within a reasonable timeframe after starting the suspected drug.

Hy's law is particularly important in the field of pharmacovigilance, as it helps healthcare providers and researchers identify potentially hepatotoxic drugs and prevent serious liver damage in patients. By following Hy's law, healthcare professionals can make informed decisions about drug therapy and minimize the risk of DILI.

Several drugs have been implicated in causing liver injury according to Hy's law, including acetaminophen, isoniazid, and methotrexate. These drugs have been associated with varying degrees of liver toxicity, ranging from mild elevations in liver enzymes to fulminant hepatic failure.

It is essential for healthcare providers to be aware of Hy's law and its implications for patient care. By recognizing the signs of DILI and promptly discontinuing the offending drug, healthcare professionals can prevent further liver damage and improve patient outcomes.

For more information on drug-induced liver injury and other related topics, please refer to the following articles:

• Drug-induced liver injury
• Hepatotoxicity
• Pharmacovigilance