Hydroxyphenamate

Hydroxyphenamate is a sedative and tranquilizer of the carbamate family. It was introduced in the 1960s in Europe, but was later withdrawn due to hepatotoxicity concerns.

Pharmacology

Hydroxyphenamate acts as a GABA receptor agonist. It enhances the effect of the neurotransmitter gamma-aminobutyric acid (GABA) on the GABA-A receptor, leading to sedative and anxiolytic effects.

Medical Uses

Hydroxyphenamate was primarily used as a sedative and tranquilizer. It was used to treat conditions such as anxiety, insomnia, and seizures. However, due to its potential for hepatotoxicity, it is no longer in use.

Side Effects

The most serious side effect of hydroxyphenamate is hepatotoxicity, which can lead to liver failure. Other side effects may include drowsiness, dizziness, and nausea.

History

Hydroxyphenamate was introduced in the 1960s in Europe. However, it was later withdrawn from the market due to concerns about hepatotoxicity.

See Also

• Carbamate
• GABA receptor
• Hepatotoxicity

Hydroxyphenamate Resources
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