Hypersegmented neutrophil

Hypersegmented neutrophil is a type of neutrophil, a white blood cell, that has an abnormally large number of segments in its nucleus. It is a characteristic finding in certain types of anemia, particularly megaloblastic anemia and pernicious anemia.

Causes[edit | edit source]

Hypersegmented neutrophils are typically caused by deficiencies in vitamin B12 or folic acid, both of which are necessary for DNA synthesis. Without these nutrients, the neutrophil's nucleus cannot divide properly, leading to an increased number of segments.

Diagnosis[edit | edit source]

Hypersegmented neutrophils are usually identified through a complete blood count (CBC) and a peripheral blood smear. In a peripheral blood smear, the neutrophils are stained and examined under a microscope. If the average number of segments in the neutrophil's nucleus is greater than five, this is considered hypersegmented.

Treatment[edit | edit source]

Treatment for hypersegmented neutrophils involves addressing the underlying cause. This usually involves supplementation with vitamin B12 or folic acid. In some cases, treatment of the underlying disease, such as pernicious anemia, may also be necessary.

See also[edit | edit source]

Hypersegmented neutrophil Resources
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