Tuber cinereum hamartoma

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(Redirected from Hypothalamic hamartomas)

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Tuber cinereum hamartoma
Hypothalamic hamartoma.jpg
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Gelastic seizures, precocious puberty, cognitive impairment, behavioral disorders
Complications Epilepsy, developmental delay
Onset Childhood
Duration Chronic
Types N/A
Causes Congenital disorder
Risks Genetic predisposition
Diagnosis MRI, EEG
Differential diagnosis Hypothalamic tumor, Craniopharyngioma, Pituitary adenoma
Prevention N/A
Treatment Surgical resection, Gamma Knife radiosurgery, Antiepileptic drugs
Medication N/A
Prognosis Variable, depends on size and location
Frequency Rare
Deaths N/A


A rare, benign brain tumor


Diagram of the hypothalamus
Location of the hypothalamus in the brain

Tuber cinereum hamartoma is a rare, benign brain tumor located in the hypothalamus. It is composed of disorganized but mature neurons and glial cells. This condition is often associated with gelastic seizures, precocious puberty, and cognitive impairment.

Anatomy and location[edit | edit source]

The tuber cinereum is a part of the hypothalamus, situated between the mammillary bodies and the optic chiasm. A hamartoma in this region is a non-cancerous growth that can affect the normal functioning of the hypothalamus.

Symptoms[edit | edit source]

The most characteristic symptom of a tuber cinereum hamartoma is gelastic seizures, which are seizures that involve sudden bursts of laughter. Other symptoms may include:

Diagnosis[edit | edit source]

Diagnosis of a tuber cinereum hamartoma typically involves imaging studies such as MRI or CT scan to visualize the lesion. Electroencephalography (EEG) may be used to assess seizure activity.

An EEG cap used for monitoring brain activity

Treatment[edit | edit source]

Treatment options for tuber cinereum hamartoma depend on the symptoms and may include:

Prognosis[edit | edit source]

The prognosis for individuals with tuber cinereum hamartoma varies. Surgical intervention can be effective in controlling seizures and other symptoms, but the risk of complications must be considered.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD