ICI-174864

ICI-174864

ICI-174864 is a selective antagonist of the 5-HT2 receptor, specifically targeting the 5-HT2A and 5-HT2C subtypes. It is a compound of interest in the field of neuropharmacology due to its potential applications in research and therapeutic contexts.

Chemical Structure and Properties

ICI-174864 is a chemical compound with the molecular formula C19H22N2O2. It is characterized by its selective binding affinity to the 5-HT2A and 5-HT2C receptors, which are subtypes of the serotonin receptor family. These receptors are G protein-coupled receptors (GPCRs) that play a crucial role in the modulation of neurotransmission in the central nervous system.

Mechanism of Action

As a selective antagonist, ICI-174864 binds to the 5-HT2A and 5-HT2C receptors, inhibiting the action of serotonin (5-HT) at these sites. This blockade can modulate various physiological and psychological processes, including mood, perception, and cognition. The selective antagonism of these receptors makes ICI-174864 a valuable tool in research for understanding the role of serotonin in the brain.

Research Applications

ICI-174864 is primarily used in preclinical research to study the function of 5-HT2 receptors. It has been employed in experiments to:

• Investigate the role of 5-HT2 receptors in psychiatric disorders such as schizophrenia, depression, and anxiety disorders.
• Explore the effects of serotonin on cognition and perception.
• Examine the potential therapeutic effects of 5-HT2 receptor modulation in various neurological disorders.

Therapeutic Potential

While ICI-174864 itself is not used as a therapeutic agent, its role as a research tool helps in the development of new drugs targeting the 5-HT2 receptors. Understanding the interaction between serotonin and these receptors can lead to the development of novel treatments for mental health disorders.

Safety and Toxicology

As with many research chemicals, the safety profile of ICI-174864 is not fully established for human use. It is primarily used in controlled laboratory settings, and its effects in humans are not well-documented.

Also see

• Serotonin receptor
• 5-HT2A receptor
• 5-HT2C receptor
• Neuropharmacology
• Antagonist (pharmacology)