IKK2
IKK2 is a protein that in humans is encoded by the IKBKB gene. IKK2, also known as IκB kinase beta, is part of the IKK complex and plays a crucial role in the NF-κB signaling pathway. This pathway is involved in many cellular processes, including inflammation, immunity, cell survival, and proliferation.
Function[edit | edit source]
IKK2 is a component of the IKK complex, which consists of two catalytic subunits, IKK1 (also known as IKKα) and IKK2 (also known as IKKβ), and a regulatory subunit, NEMO (also known as IKKγ). The IKK complex phosphorylates inhibitors of NF-κB (IκBs), leading to their degradation and the release of NF-κB. The free NF-κB then translocates to the nucleus and activates the transcription of various genes involved in inflammation, immunity, cell survival, and proliferation.
Clinical significance[edit | edit source]
Mutations in the IKBKB gene that encodes IKK2 have been associated with immunodeficiency syndromes. These mutations can lead to a decrease in IKK2 activity, resulting in impaired NF-κB activation and a subsequent decrease in immune response.
In addition, IKK2 has been implicated in the pathogenesis of various diseases, including cancer, autoimmune diseases, and inflammatory diseases. Therefore, IKK2 is considered a potential therapeutic target for these diseases.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD