IL-3
IL-3 is a type of interleukin that is produced by T cells following cell activation by antigens. IL-3 is capable of supporting the growth and differentiation of T cells, B cells, mast cells, eosinophils, megakaryocytes, and granulocytes. In the immune system, IL-3 tends to be produced by T cells and mast cells.
Function[edit | edit source]
IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with other factors such as IL-7, into lymphoid progenitor cells. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response.
Clinical Significance[edit | edit source]
IL-3 has been associated with several autoimmune diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis. It is also involved in various biological processes, including allergy, asthma, and cancer.
See Also[edit | edit source]
- Interleukin
- T cells
- B cells
- Mast cells
- Eosinophils
- Megakaryocytes
- Granulocytes
- Hematopoietic stem cells
- Myeloid
- Lymphoid
- Autoimmune diseases
- Rheumatoid arthritis
- Psoriasis
- Multiple sclerosis
- Allergy
- Asthma
- Cancer
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Contributors: Prab R. Tumpati, MD
