IL22RA1
IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a protein that in humans is encoded by the IL22RA1 gene. This protein is a part of the class II cytokine receptor family, and is a receptor for the cytokine interleukin 22 (IL-22).
Function[edit | edit source]
The IL22RA1 protein is a receptor for IL-22, which is a cytokine that contributes to the inflammatory response. IL-22 is produced by activated T cells and NK cells and can stimulate the production of acute phase proteins. IL22RA1 is expressed in tissues such as the liver, pancreas, kidney, colon, and skin.
Clinical Significance[edit | edit source]
Mutations in the IL22RA1 gene have been associated with susceptibility to psoriasis, a common skin condition that causes cells to build up rapidly on the surface of the skin. Studies have also suggested a role for IL22RA1 in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
- IL22RA1 at the National Center for Biotechnology Information
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