IL22RA1

IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a protein that in humans is encoded by the IL22RA1 gene. This protein is a part of the class II cytokine receptor family, and is a receptor for the cytokine interleukin 22 (IL-22).

Function

The IL22RA1 protein is a receptor for IL-22, which is a cytokine that contributes to the inflammatory response. IL-22 is produced by activated T cells and NK cells and can stimulate the production of acute phase proteins. IL22RA1 is expressed in tissues such as the liver, pancreas, kidney, colon, and skin.

Clinical Significance

Mutations in the IL22RA1 gene have been associated with susceptibility to psoriasis, a common skin condition that causes cells to build up rapidly on the surface of the skin. Studies have also suggested a role for IL22RA1 in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis.

See Also

• Interleukin 22
• Cytokine receptor
• Psoriasis
• Inflammatory bowel disease

External Links

• IL22RA1 at the National Center for Biotechnology Information