ING4

ING4 (Inhibitor of Growth Family Member 4) is a gene that encodes a protein involved in the regulation of cell growth, apoptosis, and tumor suppression. The ING4 protein is part of the inhibitor of growth (ING) family, which plays a crucial role in chromatin remodeling and gene expression regulation.

Function

The ING4 protein is known to interact with the p53 tumor suppressor protein, enhancing its ability to regulate cell cycle arrest and apoptosis. ING4 is also involved in the NF-kB signaling pathway, where it acts as a negative regulator, thereby inhibiting inflammation and angiogenesis.

Clinical Significance

Alterations in the ING4 gene have been associated with various types of cancer, including glioblastoma, breast cancer, and lung cancer. Loss of ING4 expression can lead to increased tumor growth and metastasis, highlighting its role as a tumor suppressor.

Interactions

ING4 has been shown to interact with several proteins, including:

• EP300 - a histone acetyltransferase involved in transcriptional activation.
• TP53 - a tumor suppressor protein that regulates the cell cycle.
• NF-kB - a protein complex that controls transcription of DNA, cytokine production, and cell survival.

Research

Ongoing research is focused on understanding the precise mechanisms by which ING4 regulates tumor suppression and its potential as a therapeutic target in cancer treatment.

See Also

• Inhibitor of Growth Family
• Tumor Suppressor Genes
• Chromatin Remodeling

External Links

• ING4 Gene - NCBI
• ING4 Protein - UniProt