INPP4B

INPP4B (Inositol polyphosphate-4-phosphatase type II B) is a gene that encodes a protein involved in the phosphoinositide signaling pathway. This protein is part of the inositol polyphosphate-4-phosphatase family, which plays a crucial role in the regulation of cellular processes such as cell growth, proliferation, and survival.

Function

The INPP4B protein is responsible for the dephosphorylation of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), a lipid second messenger involved in the PI3K/AKT signaling pathway. This pathway is critical for regulating various cellular functions, including metabolism, apoptosis, and cell cycle progression.

Clinical Significance

Alterations in the expression or function of INPP4B have been implicated in several cancers, including breast cancer, prostate cancer, and ovarian cancer. Studies suggest that INPP4B may act as a tumor suppressor gene, and its loss or reduced expression can lead to increased PI3K/AKT signaling, promoting tumorigenesis.

Research

Research on INPP4B is ongoing to better understand its role in cancer and other diseases. Investigations are focused on how modulation of INPP4B activity can influence cancer progression and whether it can be targeted for therapeutic interventions.

See Also

• Phosphoinositide 3-kinase
• AKT signaling pathway
• Tumor suppressor gene

External Links

• [INPP4B Gene - GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=INPP4B)
• [INPP4B - NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/8821)

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