IRF4
IRF4 (Interferon Regulatory Factor 4) is a protein that in humans is encoded by the IRF4 gene. It is a member of the interferon regulatory factors family of transcription factors, playing a crucial role in the regulation of immune responses.
Function[edit | edit source]
IRF4 is unique among the IRFs in its regulatory role in the immune system. It is critical for the differentiation and activation of T cells, B cells, and macrophages. In B cells, IRF4 interacts with PU.1 and Spi-B to control immunoglobulin class switch recombination and the expression of several B cell-specific genes.
Clinical significance[edit | edit source]
Mutations in the IRF4 gene have been associated with the development of various lymphomas, including multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. It has also been implicated in leukemia and melanoma.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
