IRF7
IRF7 or Interferon Regulatory Factor 7 is a protein that in humans is encoded by the IRF7 gene. It is a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes.
Function[edit | edit source]
IRF7 is a member of the interferon regulatory factors (IRF) family, which was originally discovered through their regulation of interferon and interferon-inducible genes. IRF7 is similar to IRF3 in its function, structure, and regulation. Both are key regulators of type I interferon-dependent immune responses. However, unlike IRF3, IRF7 is predominantly expressed in lymphoid tissue.
Clinical significance[edit | edit source]
Mutations in the IRF7 gene can lead to severe viral infections. This is because IRF7 is essential for the induction of type I interferon responses, which are a primary defense against viral infections. In particular, individuals with IRF7 mutations have been found to be highly susceptible to severe influenza.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IRF7 at the US National Library of Medicine Medical Subject Headings (MeSH)
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