IRX3
IRX3 (Iroquois Homeobox 3) is a protein that in humans is encoded by the IRX3 gene. It is a member of the Iroquois homeobox gene family and plays a crucial role in the early stages of human development.
Function[edit | edit source]
IRX3 is a transcription factor that belongs to the Iroquois homeobox gene family. Members of this family are involved in pattern formation of vertebrate organisms. IRX3 is known to play a role in the early stages of neural tube formation. It is also involved in the patterning of the conduction system of the heart.
Clinical significance[edit | edit source]
Mutations in the IRX3 gene have been associated with various medical conditions. For instance, a variant of the IRX3 gene has been linked to obesity. Studies have shown that people with this variant have a higher body mass index (BMI) than those without it.
In addition, IRX3 mutations have been implicated in the development of type 2 diabetes. Research suggests that the IRX3 gene may influence the risk of this disease by affecting the function of insulin-producing cells in the pancreas.
See also[edit | edit source]
References[edit | edit source]
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