ITGA11

ITGA11 or Integrin Subunit Alpha 11 is a protein that in humans is encoded by the ITGA11 gene. It is a member of the integrin family and has been associated with various biological processes, including cell adhesion, cell migration, and cell differentiation.

Function

ITGA11 is a type of integrin, a large family of proteins that mediate cell-cell and cell-extracellular matrix interactions. These proteins are integral membrane proteins composed of an alpha chain and a beta chain. ITGA11 forms a heterodimer with a beta 1 subunit and has been implicated in various biological processes such as osteoblast differentiation and collagen binding.

Clinical Significance

Alterations in the ITGA11 gene have been associated with various diseases. For instance, mutations in this gene have been linked to fibrosis, a condition characterized by the excessive accumulation of extracellular matrix components, and cancer, where it has been found to promote tumor progression and metastasis.

Research

Research on ITGA11 is ongoing, with studies focusing on its role in cell adhesion and migration, its involvement in disease processes, and its potential as a therapeutic target in conditions such as fibrosis and cancer.

See Also

• Integrin
• Cell adhesion
• Cell migration
• Cell differentiation
• Fibrosis
• Cancer

References

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