ITGA11
ITGA11 or Integrin Subunit Alpha 11 is a protein that in humans is encoded by the ITGA11 gene. It is a member of the integrin family and has been associated with various biological processes, including cell adhesion, cell migration, and cell differentiation.
Function[edit | edit source]
ITGA11 is a type of integrin, a large family of proteins that mediate cell-cell and cell-extracellular matrix interactions. These proteins are integral membrane proteins composed of an alpha chain and a beta chain. ITGA11 forms a heterodimer with a beta 1 subunit and has been implicated in various biological processes such as osteoblast differentiation and collagen binding.
Clinical Significance[edit | edit source]
Alterations in the ITGA11 gene have been associated with various diseases. For instance, mutations in this gene have been linked to fibrosis, a condition characterized by the excessive accumulation of extracellular matrix components, and cancer, where it has been found to promote tumor progression and metastasis.
Research[edit | edit source]
Research on ITGA11 is ongoing, with studies focusing on its role in cell adhesion and migration, its involvement in disease processes, and its potential as a therapeutic target in conditions such as fibrosis and cancer.
See Also[edit | edit source]
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD