Imiclopazine
Imiclopazine is a chemical compound that belongs to the class of phenothiazine derivatives. It is primarily known for its use as an antipsychotic and antihistamine agent.
Chemical Structure and Properties[edit | edit source]
Imiclopazine has a chemical structure similar to other phenothiazine derivatives, which are characterized by a three-ring system with a sulfur and nitrogen atom. The molecular formula of Imiclopazine is C19H22N2S.
Pharmacology[edit | edit source]
Imiclopazine functions by blocking dopamine receptors in the brain, which helps in reducing symptoms of psychosis. Additionally, it has antihistamine properties, making it effective in treating allergic reactions. The drug is known to have sedative effects due to its action on the central nervous system.
Medical Uses[edit | edit source]
Imiclopazine is used in the treatment of various psychiatric disorders, including schizophrenia and bipolar disorder. It is also used to manage severe allergic reactions and pruritus due to its antihistamine properties.
Side Effects[edit | edit source]
Common side effects of Imiclopazine include drowsiness, dry mouth, and constipation. More severe side effects can include tardive dyskinesia, neuroleptic malignant syndrome, and agranulocytosis.
History[edit | edit source]
Imiclopazine was first synthesized in the mid-20th century as part of the development of phenothiazine derivatives. It was initially investigated for its antipsychotic properties and later found to have significant antihistamine effects.
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Contributors: Prab R. Tumpati, MD