Inebilizumab
Inebilizumab is a monoclonal antibody designed for the treatment of neuromyelitis optica, a rare neurological condition. It is marketed under the brand name Uplizna.
Mechanism of Action[edit | edit source]
Inebilizumab works by binding to a specific protein, CD19, found on the surface of B cells. By doing this, it helps to reduce the number of B cells in the body, which are believed to play a key role in the development of neuromyelitis optica.
Uses[edit | edit source]
Inebilizumab is used for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.
Side Effects[edit | edit source]
Common side effects of Inebilizumab include urinary tract infection, back pain, joint pain, headache, and high blood pressure. Serious side effects can include infection, liver problems, and depression.
History[edit | edit source]
Inebilizumab was approved by the Food and Drug Administration (FDA) in June 2020, making it the second drug approved for the treatment of NMOSD.
References[edit | edit source]
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
