Inocoterone

Inocoterone is a synthetic, steroidal antiandrogen that was never marketed. It is an antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). Inocoterone has been studied in the treatment of acne and hirsutism in women.

Chemistry

Inocoterone, also known as 17α-ethynyl-3β-hydroxy-19-norandrost-5-en-17-one, is a synthetic estrane steroid and a derivative of 19-nortestosterone. It is more specifically a derivative of ethisterone (17α-ethynyltestosterone), with an additional hydroxyl group at the C3β position.

Pharmacology

Inocoterone acts as an antagonist of the AR, the biological target of androgens like testosterone and DHT. This means that it competes with these androgens for binding to the AR and thereby prevents them from exerting their biological effects in the body. As such, inocoterone has antiandrogenic effects.

Medical uses

Inocoterone has been studied in the treatment of acne and hirsutism in women. It has been found to be effective in the treatment of these conditions, presumably due to its antiandrogenic effects.

See also

• List of steroidal antiandrogens

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