Insulin like 6

Insulin-like 6 (also known as INSL6) is a protein that in humans is encoded by the INSL6 gene. It is a member of the insulin family of hormones, which play critical roles in metabolism, growth, and development.

Structure

The INSL6 gene is located on the short (p) arm of chromosome 19 at position 13.2. The protein encoded by this gene is a member of the insulin superfamily. Most of the superfamily members are secreted proteins that play critical roles in the regulation of metabolism, growth, and cell survival.

Function

INSL6 is a hormone that is primarily expressed in the testis and has been implicated in spermatogenesis, the process by which spermatozoa are produced. It is also expressed in other tissues, including the ovary and brain, suggesting that it may have additional functions.

Clinical significance

Mutations in the INSL6 gene have been associated with certain forms of infertility. In addition, INSL6 may play a role in the development of insulin resistance, a condition that can lead to type 2 diabetes and metabolic syndrome.

See also

• Insulin
• Insulin family
• Spermatogenesis
• Infertility
• Insulin resistance
• Type 2 diabetes
• Metabolic syndrome

References

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