Interleukin-25

Interleukin-25 (IL-25), also known as Interleukin-17E (IL-17E), is a protein that in humans is encoded by the IL25 gene. It is a member of the interleukin-17 family of cytokines, which are involved in numerous immune system functions.

Function

IL-25 is produced by epithelial cells and can stimulate the production of other cytokines such as interleukin-4, interleukin-5, and interleukin-13 from Th2 cells. This leads to an increase in the immune response against parasitic infections. IL-25 also plays a role in allergic responses, promoting the effects of Th2 cells and eosinophils, cells that are often found in high numbers in allergic reactions and asthma.

Clinical significance

Research has shown that IL-25 may play a role in the development of autoimmune diseases, including asthma and inflammatory bowel disease. It has been suggested that blocking the action of IL-25 may be a potential therapeutic strategy in treating these conditions.

See also

• Interleukin
• Cytokine
• Immune system
• Autoimmune disease

External links

• IL25 at the US National Library of Medicine Medical Subject Headings (MeSH)