Interleukin-5 receptor

Interleukin-5 receptor (also known as IL-5R) is a type of protein that in humans is encoded by the IL5RA gene. It is a part of the cytokine receptor family, specifically the type I cytokine receptors, and plays a crucial role in the immune system's response to infection and inflammation.

Structure

The Interleukin-5 receptor is a heterodimeric protein complex, composed of an alpha chain (IL5RA) and a beta chain (IL5RB). The alpha chain binds specifically to IL-5, while the beta chain is shared with the receptors for IL-3 and GM-CSF.

Function

The primary function of the Interleukin-5 receptor is to mediate the effects of IL-5, a cytokine that is involved in the maturation and activation of eosinophils. Eosinophils are a type of white blood cell that play a key role in the immune response, particularly in the defense against parasitic infections and in the pathogenesis of allergic reactions.

Clinical significance

Abnormalities in the Interleukin-5 receptor can lead to a variety of health problems. Overexpression of the receptor can result in eosinophilia, a condition characterized by an abnormally high number of eosinophils in the blood. This can lead to tissue damage and inflammation in various parts of the body.

On the other hand, mutations in the IL5RA gene that lead to a non-functional Interleukin-5 receptor can result in a rare immunodeficiency syndrome known as Hyper-IgM syndrome type 4.

See also

• Interleukin-5
• Cytokine receptor
• Eosinophil granulocyte
• Hyper IgM syndrome

References

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