Interleukin 10 receptor, beta subunit
Interleukin 10 receptor, beta subunit (also known as IL10RB) is a protein that in humans is encoded by the IL10RB gene. It is a part of the interleukin-10 receptor family, which plays a crucial role in immunology and cell signaling.
Function[edit | edit source]
The IL10RB protein is an essential part of the receptor complex for interleukin-10 (IL10) and interleukin-22 (IL22). It interacts with the alpha subunit of these cytokines and initiates a signal transduction pathway leading to the activation of the JAK-STAT signaling pathway. This pathway is involved in a wide variety of processes including cell proliferation, differentiation, apoptosis, and immune response.
Clinical significance[edit | edit source]
Mutations in the IL10RB gene have been associated with inflammatory bowel disease and other autoimmune diseases. In addition, the IL10RB protein is a target for several therapeutic strategies in the treatment of autoimmune diseases and cancer.
See also[edit | edit source]
- Interleukin-10 receptor
- Interleukin-10
- Interleukin-22
- JAK-STAT signaling pathway
- Inflammatory bowel disease
- Autoimmune diseases
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
