Interleukin 10 receptor, beta subunit

Interleukin 10 receptor, beta subunit (also known as IL10RB) is a protein that in humans is encoded by the IL10RB gene. It is a part of the interleukin-10 receptor family, which plays a crucial role in immunology and cell signaling.

Function

The IL10RB protein is an essential part of the receptor complex for interleukin-10 (IL10) and interleukin-22 (IL22). It interacts with the alpha subunit of these cytokines and initiates a signal transduction pathway leading to the activation of the JAK-STAT signaling pathway. This pathway is involved in a wide variety of processes including cell proliferation, differentiation, apoptosis, and immune response.

Clinical significance

Mutations in the IL10RB gene have been associated with inflammatory bowel disease and other autoimmune diseases. In addition, the IL10RB protein is a target for several therapeutic strategies in the treatment of autoimmune diseases and cancer.

See also

• Interleukin-10 receptor
• Interleukin-10
• Interleukin-22
• JAK-STAT signaling pathway
• Inflammatory bowel disease
• Autoimmune diseases

References

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