Iodine (125I) human albumin

Iodine (125I) Human Albumin

Iodine (125I) Human Albumin is a radiopharmaceutical used in nuclear medicine for diagnostic purposes. It consists of human albumin, a protein found in blood plasma, labeled with the radioactive isotope iodine-125 (125I). This article provides a detailed overview of Iodine (125I) Human Albumin, including its uses, properties, and precautions.

Uses

Iodine (125I) Human Albumin is primarily used in nuclear medicine imaging studies, specifically for the evaluation of blood volume and plasma volume. It is commonly employed in studies related to cardiac function, such as determining cardiac output and assessing blood flow in various organs.

The radiolabeled albumin allows for the measurement of blood volume by tracking the distribution of the radioactive iodine in the body. This information can be valuable in diagnosing conditions such as congestive heart failure, liver disease, and certain types of kidney disorders.

Properties

Iodine-125 (125I) is a radioactive isotope of iodine with a half-life of approximately 60 days. It emits gamma radiation, which can be detected by specialized imaging equipment. The gamma rays emitted by 125I have a relatively low energy, making them suitable for imaging purposes.

Human albumin, the carrier molecule for the radioactive iodine, is a protein that plays a crucial role in maintaining osmotic pressure and transporting various substances in the blood. It is obtained from human plasma and undergoes rigorous purification processes to ensure its safety and efficacy.

Precautions

As with any radiopharmaceutical, the use of Iodine (125I) Human Albumin requires careful consideration of radiation safety measures. It should only be administered by trained healthcare professionals who are familiar with the handling and disposal of radioactive materials.

Patients receiving Iodine (125I) Human Albumin should be informed about the potential risks associated with radiation exposure. The dosage administered should be tailored to each individual's specific needs, taking into account factors such as body weight, age, and overall health.