Iohexol

Iohexol is a radiographic contrast agent that is commercially sold under the trade name Omnipaque. It is utilized in various radiological procedures to visualize structures and vessels within the body, providing clearer imaging results. Iohexol is particularly known for its osmolality characteristics, which make it more compatible with the human body than some older contrast agents.

Iohexol Structural Formula

Uses and Concentrations

Iohexol is available in multiple concentrations, ranging from 140 to 350 milligrams of iodine per milliliter. The specific concentration chosen often depends on the imaging procedure and the part of the body being studied. For instance:

• Omnipaque 350: This concentration is frequently used as a contrast agent during coronary angiography, a procedure that visualizes the blood vessels of the heart.

Osmolality

A notable property of iohexol is its osmolality. The osmolality of a solution describes its solute concentration, and in the context of contrast agents, it's a critical factor in determining the agent's compatibility with the body and potential side effects.

For iohexol:

• Osmolality ranges from 322 mOsm/kg—which is approximately 1.1 times that of blood plasma—to 844 mOsm/kg, nearly three times the osmolality of blood.

Although this range might seem high, iohexol is classified as a low-osmolality contrast agent. Older agents, such as diatrizoate, can have osmolalities that are over twice as high as iohexol, potentially increasing the risk of adverse reactions.

Adverse Effects and Precautions

Like all contrast agents, iohexol has a potential for side effects, which can range from mild reactions like warmth or a metallic taste in the mouth to more severe allergic reactions. It's essential for patients to inform their healthcare providers about any known allergies or previous reactions to contrast agents.

See Also

• Radiographic contrast agent
• Coronary angiography
• Medical imaging

External links

• Omnipaque (Iohexol) injection, solution

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