Isocodeine

An opioid analgesic and antitussive drug

Isocodeine
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Isocodeine is an opioid analgesic and antitussive drug, which is a derivative of codeine. It is used in the treatment of mild to moderate pain and as a cough suppressant.

Chemical structure and properties

Chemical structure of Isocodeine

Isocodeine is chemically similar to codeine, with the primary difference being the position of the hydroxyl group on the morphinan skeleton. This structural variation can influence its pharmacological properties and metabolism.

Pharmacology

Isocodeine acts primarily as a mu-opioid receptor agonist, which is responsible for its analgesic effects. It also has activity at the kappa-opioid receptor, contributing to its antitussive properties. The drug is metabolized in the liver, primarily by the cytochrome P450 enzyme system, and is excreted in the urine.

Medical uses

Isocodeine is used for the relief of mild to moderate pain and as a cough suppressant. It is often prescribed when other analgesics are not effective or when a patient requires both pain relief and cough suppression.

Side effects

Common side effects of isocodeine include drowsiness, nausea, vomiting, and constipation. As with other opioids, there is a risk of addiction and tolerance with prolonged use. Patients should be monitored for signs of misuse and dependence.

Legal status

The legal status of isocodeine varies by country. In some regions, it is classified as a controlled substance due to its potential for abuse and dependence.

Related pages

• Codeine
• Opioid
• Analgesic
• Antitussive