Isomethadone

Isomethadone is a synthetic opioid that is chemically similar to methadone. It is used in the treatment of chronic pain and opioid dependence.

History

Isomethadone was first synthesized in the 1940s by the German pharmaceutical company Hoechst AG. It was developed as a potential alternative to morphine, which was in short supply during World War II.

Pharmacology

Isomethadone acts on the mu-opioid receptor, the primary site of action for most opioids. It is a full agonist, meaning it fully activates the receptor and produces a maximal response. This results in analgesia, sedation, and other effects characteristic of opioid drugs.

Medical uses

Isomethadone is used in the treatment of chronic pain and opioid dependence. It is often used as a second-line treatment when other opioids are not effective or are not tolerated.

Side effects

Like all opioids, isomethadone can cause a range of side effects. These can include nausea, vomiting, constipation, drowsiness, and respiratory depression. It can also cause physical dependence and withdrawal symptoms if stopped abruptly.

See also

• Methadone
• Opioid
• Opioid dependence
• Chronic pain

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External links

• DrugBank: Isomethadone
• PubChem: Isomethadone

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