JNJ-18038683
JNJ-18038683 is a drug that was developed by Johnson & Johnson for the potential treatment of cognitive disorders, insomnia, and depression. It acts as a selective 5-HT2A receptor antagonist and 5-HT2C receptor inverse agonist, and has been shown to enhance cognition in animal studies.
Pharmacology[edit | edit source]
JNJ-18038683 is a serotonin antagonist and inverse agonist at the 5-HT2A and 5-HT2C receptors. These receptors are part of the serotonin system, which plays a key role in regulating mood, cognition, and sleep. By blocking the activity of these receptors, JNJ-18038683 may help to improve symptoms in conditions such as cognitive disorders, insomnia, and depression.
Clinical trials[edit | edit source]
JNJ-18038683 has undergone Phase I clinical trials for the treatment of cognitive disorders, insomnia, and depression. However, the results of these trials have not been publicly disclosed, and it is unclear whether the drug will proceed to Phase II clinical trials.
See also[edit | edit source]
- 5-HT2A receptor
- 5-HT2C receptor
- Serotonin antagonist
- Inverse agonist
- Cognitive disorders
- Insomnia
- Depression
References[edit | edit source]
| JNJ-18038683 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
