JQ1
JQ1 is a small molecule inhibitor that targets the Bromodomain and Extra-Terminal motif (BET) family of proteins, specifically BRD4. It was first developed by the research group of James E. Bradner at the Dana-Farber Cancer Institute and has been widely used in preclinical research to study the role of BET proteins in various diseases, including cancer, inflammation, and cardiovascular disease.
Structure and Mechanism of Action[edit | edit source]
JQ1 is a thieno-triazolo-1,4-diazepine that binds to the bromodomains of BET proteins, preventing them from interacting with acetylated histones. This disrupts the ability of BET proteins to regulate gene expression, leading to changes in cellular behavior.
Applications in Research[edit | edit source]
JQ1 has been used in a wide range of preclinical studies to investigate the role of BET proteins in disease. For example, it has been shown to inhibit the growth of various types of cancer cells, including those from leukemia, melanoma, and lung cancer. It has also been used to study the role of BET proteins in inflammation and cardiovascular disease.
Clinical Development[edit | edit source]
While JQ1 itself is not currently in clinical development, it has served as a prototype for the development of other BET inhibitors that are being tested in clinical trials for various types of cancer and other diseases.
Safety and Side Effects[edit | edit source]
As a research tool, JQ1 is not intended for use in humans and its safety profile has not been fully evaluated. However, studies in animals have suggested that it may have potential side effects, including weight loss and decreased fertility.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
 | This oncology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
