Jazz Pharmaceuticals Ireland Ltd

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Jazz Pharmaceuticals Ireland Ltd

Jazz Pharmaceuticals Ireland Ltd is a pharmaceutical drug manufacturer / distributor from Athlone, Ireland with revenues of over $1.618 billion annually in 2017[1].

Overview

Jazz Pharmaceuticals is an Ireland based global biopharmaceutical company with the following lead products.

  • Xyrem® (sodium oxybate) oral solution, the only product approved by the U.S. Food and Drug Administration, or FDA, and marketed in the U.S. for the treatment of both cataplexy and excessive daytime sleepiness, or EDS, in both adult and pediatric patients with narcolepsy;
  • Sunosi® (solriamfetol), a product approved by the FDA and marketed in the U.S. to improve wakefulness in adult patients with EDS associated with narcolepsy or obstructive sleep apnea, or OSA, and also approved in Europe in January 2020 by the European Commission, or EC;
  • Defitelio® (defibrotide sodium), a product approved in the U.S. for the treatment of adult and pediatric patients with hepatic veno-occlusive disease, or VOD, also known as sinusoidal obstruction syndrome, or SOS, with renal or pulmonary dysfunction following hematopoietic stem cell transplantation, or HSCT, and in Europe (where it is marketed as Defitelio® (defibrotide)) for the treatment of severe VOD in adults and children undergoing HSCT therapy;
  • Erwinaze® (asparaginase Erwinia chrysanthemi), a treatment approved in the U.S. and in certain markets in Europe (where it is marketed as Erwinase®) for patients with acute lymphoblastic leukemia, or ALL, who have developed hypersensitivity to E. coli-derived asparaginase; and
  • Vyxeos® (daunorubicin and cytarabine) liposome for injection, a product approved in the U.S. and in Europe (where it is marketed as Vyxeos® liposomal 44 mg/100 mg powder for concentrate for solution for infusion) for the treatment of adults with newly-diagnosed therapyrelated acute myeloid leukemia, or t-AML, or AML with myelodysplasia-related changes, or AML-MRC.

History

Major acquisitions

In January 2021, Jazz announced it would acquire GW Pharmaceuticals for $7.2 billion.

Board of directors

Products in development

JZP458

Cannabidiol

Nabiximols

Lurbinectedin

  • 1L treatment SCLC(small cell lung cancer), in combination with atezolizumab
  • Basket trial: advanced urothelial cancer, large cell neuroendocrine tumor of the lung, HRD+ cancers

JZP351

  • AML or HR-MDS >60 yrs (AML18)
  • Newly diagnosed adults with standard - and HR-AML (AMLSG)
  • Newly diagnosed <22 yrs with AML (COG)
  • HR-MDS (EMSCO)
  • Newly diagnosed older adults with HRAML
  • Low Intensity Dosing for higher risk MDS

JZP351 + venetoclax

  • De novo AML
  • Relapsed refractory AML  

JZP351 + other approved therapies

  • R/R AML or HMA Failure MDS2
  • First-line, fit AML (Phase 1b)
  • Low Intensity Therapy for first-line, unfit AML (Phase 1b)

Suvecaltamide (JZP385)

JZP150

JZP324

  • Oxybate extended-release formulation

CombiPlex

  • Exploratory activities

Pre-clinical

Exosome candidates

  • Exosome NRAS
  • Solid tumors/Hematological malignancies

Pre-clinical

JZP341

  • ALL/LBL

Pre-clinical

Pan-RAF Inhibitor Program

  • RAF & RAS mutant tumors

External links


5 stars

Reviews & Ratings

5.00
(one vote)
  • Rating Criteria: 5 Stars – Outstanding, 1 Star – Unsatisfactory

1

Awards

  • Nominate Jazz Pharmaceuticals Ireland Ltd for an outstanding quality / service award!


Resources

Frequently asked questions

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  1. "Jazz Pharmaceuticals PLC 2017 Annual Report (Form 10-K)". sec.gov. U.S. Securities and Exchange Commission. February 2018. Archived from the original on 2018-04-16. Retrieved 2018-07-19.
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